Challenges treating mood disorders

An interview wih Dr Aideen Moran & Dr Doreen O’Rourke

Q: What are the most significant challenges facing clinicians today when treating mood disorders?

A: Aideen: Adherence to medication can be a challenge.

Doreen: Yes, particularly when the patient feels well. It’s important to explain to patients the rationale for treatment and continuing on treatment during remission and recovery.

Aideen: It’s during maintenance that many patients stop taking their medications. Another challenge we face is that there is also still a massive stigma about being on antidepressants in Ireland.

Q: How do you define remission in depression?

A: Aideen: I think it is when a patient returns back to usual life and useful function. Social and occupational function. Most people start to think they are okay and to feel better if they can return to work.

Q: What’s your opinion on combining psychiatric and psychotherapeutic approaches to care?

A: Aideen: Both are important. It is about integrated approaches – looking at genetic markers, taking account of the environment and in this we really need psychotherapies.

Doreen: Yes it’s about integrative and not reductive care, and collaborating in order to achieve patient recovery.

Q: What would you say is the potential for approaches such as biomarker-based screening or stratified medicine as predictors of pharmacological benefit?

A: Both: We don’t have any biomarkers to use in everyday practice as yet. It would be good to have biomarkers to identify slow metabolizers, but we can determine from clinical responses many of the patient’s characteristics.

Aideen: In many other fields of medicine, people link being able to quantify a response with being able to show that a treatment is working.

Doreen: Yet in some ways having measurable markers of response would change the patient-psychiatrist relationship in depression, away from one where chatting and talking predominate.

Q: What have been the most significant advances in the field of depression research lately?

A: Doreen: It’s hard to know – I think it is good that there has been a lot of re-evaluation of previous evidence, as well as attempts to link preclinical findings with clinical findings.

Aideen: Research that lows for a better understanding of the need for individualization of medication, based on genetics, the patient environment, the type or subtype of depression.

Q: Have you had any patients for whom you believe their cultural and/or social background has had a significant impact on their prognosis?

A: Aideen: Yes, social and cultural barriers can exist that mean patients drop out of treatment for their depression. But, these issues aren’t unique to psychiatry and people have a right to choose.

Disclaimers: The views and opinions expressed on this page do not necessarily reflect those of Lundbeck.
Country selection
We are registering that you are located in Brazil - if that's correct then please continue to Progress in Mind Brazil
You are leaving Progress in Mind
Le informazioni contenute nel nuovo sito prescelto possono non essere conformi al D.Ivo 219/06 che regola la pubblicità dei medicinali per uso umano e le opinioni espresse non riflettono necessariamente le posizioni dell’azienda, non sono da essa avvallate.
Accesso riservato a Operatori Sanitari
Per accedere si prega di registrarsi o, in caso sia già stato fatto, di autenticarsi
L’accesso a Progress in Mind Italia è consentito unicamente agli Operatori Sanitari (medici e farmacisti). I contenuti di questo sito sono prodotti da un team di Operatori Sanitari il cui obiettivo è presentare le ultime novità in ambito psichiatrico e neurologico, attraverso interviste, registrazioni audio/video di seminari con opinion leader, report e sintesi di congressi sia internazionali che nazionali. Per poter accedere al sito è quindi necessario registrarsi e fornire alcuni dati così da poter verificare che l‘utente sia un Operatore Sanitario.
Please confirm your email
We have just sent you an email, with a confirmation link.
Before you can gain full access - you need to confirm your email.
The information on this site is exclusively intented for health care professionals.
All the information included in the Website is related to products of the local market and, therefore, directed to health professionals legally authorized to prescribe or dispense medications with professional practice. The technical information of the drugs is provided merely informative, being the responsibility of the professionals authorized to prescribe drugs and decide, in each concrete case, the most appropriate treatment to the needs of the patient.
Register for access to Progress in Mind in your country